Current Clinical Trials (2015)

SafeHer

The aim of this trial is to compare the standard way of administering the drug Herceptin into a vein (intravenous) with administering it into tissue (subcutaneous). This new method is much quicker, taking only 5 minutes to administer, it is potentially safer because it is not intravenous. Our hope for the future is for patients to be able to administer this themselves, resulting in lower costs for the NHS. 

If you would like to find out more information about this trial please do not hesitate to contact Ruth McCrea Breast Research Nurse on 01279 827396.

 

Triple Negative Trial (Known as the TNT trial)

The aim of this study is to compare a different type of chemotherapy with the standard chemotherapy. This is for patients whose cancer is more challenging to treat due to being triple negative (this means non-hormonal and non HER-2+ breast cancer).

If you would like to find out more information about this trial please do not hesitate to contact Ruth McCrea Breast Research Nurse on 01279 827396.

 

EPHOS-B

The aim of the study is to administer the drugs Herceptin and/or Lapatinib (which are known as targeted therapy) to patients prior to their surgery. At the moment Herceptin is administered to patients for 1 year after surgery. The trial is seeking to establish if this has more long term survival benefits, as well as assessing long-term risk factors.

If you would like to find out more information about this trial please do not hesitate to contact Ruth McCrea Breast Research Nurse on 01279 827396.

 

Kamila

The aim of this trial is to assess the safety and efficacy of a novel therapy known as T-DM1. This therapy takes the chemotherapy directly to the cancer cell before it’s released, thereby reducing the usual toxic side effects of chemotherapy. As a result of studying this drug it is now licensed for use in America and Europe.

If you would like to find out more information about this trial please do not hesitate to contact Caroline Turner Breast Research Nurse on 01279 827396.

 

Intra-Operative Radio Therapy (Known as IORT)

This trial is to test a new form of radio therapy that is administered during surgery. At the moment patients receive external boom radio therapy over 5-8 days, with this new intra-operative procedure the tumour-bed boost is given at the time of surgery. This means the patient’s number of visits to the hospital is reduced. Currently 4 hospitals in the UK have the intra-beam machine used in this trial. We are trialling Intra-Operative Radio Therapy in the hope of reducing incidents of recurring breast cancer in patients with a higher grade of cancer. We aim to find out if intra-operable radio therapy is superior to standard external beam radio therapy.

If you would like to find out more information about this trial please do not hesitate to contact Jan Hanley Breast Research Nurse on 01279 827396.

 

POETIC

This is a trial of Perioperative Endocrine Therapy-Individualising Care (POETIC). This trial is for post-menopausal women with breast cancer. It is looking at whether having hormone therapy for two weeks before and two weeks after surgery helps improve outcomes in postmenopausal women with breast cancer. Patients are now in follow up. Details about this trial are available by telephone on 01279 827 396.

4EverUK

4EverUK is a Phase IV multi-centre, open label study of postmenopausal women with oestrogen receptor positive, locally advanced or metastatic breast cancer treated with Everolimus (RAD001) in combination with exemestane, with exploratory epigenetic marker analysis. Details about this trial are by telephone on 01279 827 396.

JACS

A cohort study of joint and muscle aches, pains and stiffness in women with primary breast cancer. For more details on this trial please call us on 01279 827 396.

Questionnaire Studies

Bridging the Age Gap in Breast Cancer: Improving Outcomes for Older Women

The aim of this questionnaire study is to gather the views and opinions of women over the age of 75 who have had treatment for breast cancer in the last 5 years. The information from this study will support older women in the future who are given a choice of treatment.

If you would like to find out more information about this trial please do not hesitate to contact Ruth McCrea Breast Research Nurse on 01279 827396.

Fertility Issues in Young Women with Breast Cancer

The aim of this questionnaire study is to understand the beliefs and attitudes of both patients and health professionals surrounding fertility issues in young women with breast cancer.